Which of the following was the greatest issue leading to the monroe doctrine? 1the united states was concerned about renewed european colonization efforts in the wake of latin american independence movements. 2the united states feared retaliation from spain, as the latter was bitter over the louisiana purchase from france, who had only recently regained the territory. 3the united states recognized that diplomacy was the best method to acquire new territory and wanted to assure europe of its intentions to continue peaceful relations. 4the united states had gained significant property in recent years, was having trouble establishing control in those areas, and needed justification for expanding the federal military.